P4-498: NEUTROPHIL GRANULE PROTEINS INHIBIT AMYLOID BETA AGGREGATION AND NEUROTOXICITY
نویسندگان
چکیده
منابع مشابه
Attenuated amyloid-beta aggregation and neurotoxicity owing to methionine oxidation.
Aggregation of the amyloid-beta (Abeta) peptide into amyloid plaques is a characteristic feature of Alzheimer's disease neuropathogenesis. We and others have previously demonstrated delayed Abeta aggregation as a consequence of oxidizing a single methionine residue at position 35 (Met-35). Here, we examined the consequences of Met-35 oxidation on the extremely aggregation-prone peptides Abeta1-...
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ژورنال
عنوان ژورنال: Alzheimer's & Dementia
سال: 2019
ISSN: 1552-5260
DOI: 10.1016/j.jalz.2019.08.044